Dynamic oxygen-enhanced MRI reflects diffusing capacity of the lung.

Yoshiharu Ohno¹, Hiroto Hatabu, Daisuke Takenaka

¹Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. yosirad@med.kobe-u.ac.jp

|July 12, 2002

Summary

Dynamic oxygen-enhanced MRI shows promise for assessing lung diffusing capacity. This technique may provide valuable insights into lung function, particularly in conditions like emphysema.

Area of Science:

Medical Imaging
Pulmonary Medicine
Biophysics

Background:

Pulmonary emphysema impairs lung diffusing capacity.
Accurate assessment of diffusing capacity is crucial for managing lung diseases.
Current methods for assessing diffusing capacity can be invasive or limited.

Purpose of the Study:

To evaluate the clinical feasibility of dynamic oxygen-enhanced MRI.
To determine if dynamic oxygen enhancement correlates with regional lung diffusing capacity.
To explore the potential of MRI-based oxygen enhancement imaging for mapping diffusing capacity.

Main Methods:

Employed a respiratory-synchronized inversion recovery single-shot turbo spin-echo sequence on a 1.5 T MRI scanner.
Administered 100% oxygen inhalation to participants.
Analyzed maximum mean relative enhancement ratios in defined lung regions of interest.
Compared enhancement ratios between 10 emphysema patients and 7 healthy volunteers.
Correlated enhancement ratios with diffusing lung capacity for carbon monoxide (%DL(CO)).

Main Results:

Significantly decreased maximum mean relative enhancement ratios were observed in emphysema patients compared to healthy volunteers (P = 0.0008).
A strong correlation (r² = 0.83) was found between maximum mean relative enhancement ratio and %DL(CO).

Conclusions:

Dynamic oxygen-enhanced MRI is feasible in a clinical setting.
The technique shows potential to reflect regional lung diffusing capacity.
Oxygen-enhanced MRI may offer a non-invasive method for creating maps of lung diffusing capacity.

Related Experiment Videos

Dynamic oxygen-enhanced MRI reflects diffusing capacity of the lung.

Related Concept Videos

Deep Learning Reconstruction Specialized for Inner Ear: Improving Image Quality and Anatomical Structure Visualization as Compared with Conventional Hybrid-Type Iterative Reconstruction on High-Definition CT.

Paraseptal Emphysema and Interstitial Lung Abnormalities in AGES-Reykjavik Study.

Deep learning-based motion correction: cardiac motion artifact and image quality improvements on chest CT.

Reverse Encoding Distortion Correction of Female Pelvic Diffusion-weighted Imaging on a 1.5-T MR System: Influence on Image Quality and Apparent Diffusion Coefficient Measurements for Both In Vitro and In Vivo Studies.

Comparing the Perfusion and Functional Assessment Capabilities of Electrocardiography- and Photoplethysmography-monitored Phase-resolved Functional Lung and Dynamic Contrast-enhanced Perfusion MR Imaging.

Comparison of biomechanical assessment between upright and supine inspiratory-expiratory area-detector CT in progressive pulmonary fibrosis.

3D Printing of Subject-Specific Passive Shims for In Vivo Small-Animal Magnetic Resonance Imaging.

Image Encoding With Blipped Gradients in an Echo Train.

Joint Reconstruction of Multiple b-Values and Multiple Directions for Accelerating Diffusion Kurtosis Imaging.

Generative MR Multitasking With Complex-Harmonic Cardiac Encoding: Bridging the Gap Between Gated Imaging and Real-Time Imaging.

Combined ADC and T<sub>2</sub> Mapping in the Prostate Using a 3D Reduced FOV Sequence.

Real-Time Targeted Slice Reacquisition for Motion-Corrupted Fetal Diffusion MRI.

Vascular Smooth Muscle Myosin 2 Filaments Dynamically Assemble and Stabilize During Induced Contractility.

CRISPR-mediated targeting of the <i>LMNA</i> c.745C>T mutation enhances survival and cardiac function in congenital muscular dystrophy.

A Multicenter Cohort Study of 3805 RibXcar Cases: Safety and Efficacy in Incisionless Rib Remodeling.

Structural Gains Without Symptomatic Benefit After Microfracture During High Tibial Osteotomy.

Coexistence of Multiple Endocrine Neoplasia Type 2B and Centri-Acinar Emphysema With Alpha-1 Antitrypsin Deficiency: A Case Report.

Inter-Observer Variability of Gerd-Related Metrics on High-Resolution Manometry and Calculation of the Milan Score.

Related Experiment Videos

Dynamic oxygen-enhanced MRI reflects diffusing capacity of the lung.

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

Related Concept Videos

Related Articles