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Microarrays and genetic epidemiology: a multipurpose tool for a multifaceted field
Dennise D Dalma-Weiszhausz1, Marina E Chicurel, Thomas R Gingeras
1Affymetrix, Inc, Santa Clara, California 95051, USA.
Genetic Epidemiology
|July 12, 2002
Summary
Microarrays are powerful tools for genetic epidemiology, enabling the analysis of thousands of genetic data points. This review focuses on how array design impacts infectious disease studies, improving genetic variation detection and data comparison.
Area of Science:
- Molecular biology
- Epidemiology
- Bioinformatics
Background:
- Genetic epidemiology utilizes large-scale genetic data analysis.
- Microarrays allow simultaneous monitoring of thousands of genetic or expression data points.
- Array design is crucial for specific epidemiological applications.
Purpose of the Study:
- To review how array design is dictated by its intended use in genetic epidemiology.
- To emphasize the application of microarrays in infectious disease epidemiology.
- To present array designs for genotyping, expression profiling, and fingerprinting.
Main Methods:
- Review of array design principles for various applications.
- Illustration of array applications with recent epidemiological studies.
- Discussion of design options for detecting multiple genetic variations.
Main Results:
- Microarrays offer global views of gene identity and function.
- Specific array designs can detect multiple genetic variations effectively.
- Reliability, accessibility, and data sharing of array-generated fingerprints are examined.
Conclusions:
- Microarray technology significantly advances genetic epidemiology.
- Careful array design is essential for successful epidemiological studies.
- Future directions include improving data sharing and comparison across studies.