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Direct thioesterification from carboxylic acids and thiols catalyzed by a Brønsted acid
Shinya Iimura1, Kei Manabe, Shū Kobayashi
1Graduate School of Pharmaceutical Sciences, University of Tokyo, CREST, Japan Science and Technology Corporation (JST), Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Chemical Communications (Cambridge, England)
|July 18, 2002
Abstract:
In the presence of a catalytic amount of trifluoromethanesulfonic acid, free carboxylic acids reacted with free thiols directly to afford the corresponding thioesters in high yields.