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[Structure and function of the microcirculatory bed in the preserved heart]
Insights
Medium 199 best preserves heart microcirculation and function during hyperthermia. Other solutions like salt solutions or plasma cause significant cardiac and microcirculatory issues.
Area of Science:
- Cardiovascular Physiology
- Organ Preservation
- Microcirculation Research
Context:
- Hyperthermia necessitates effective organ preservation strategies.
- Evaluating conservants for cardiac surgery is critical.
- Understanding microcirculatory responses to perfusion is key.
Purpose:
- To assess the impact of different conservants on cardiac microcirculation and activity during hyperthermal perfusion.
- To compare the efficacy of salt solution, cryoprecipitated plasma, and Medium 199.
Summary:
- Medium 199 demonstrated minimal microcirculatory changes and satisfactory cardiac activity parameters.
- Salt solution and hemodilution led to significant microcirculatory disorders and poor cardiac function.
- Cryoprecipitated plasma showed fewer microcirculatory issues but did not ensure reliable cardiac safety.
- Blood capillaries and postcapillary-venular vessels exhibited the highest structural lability.
Impact:
- Identifies Medium 199 as a superior conservant for cardiac preservation during hyperthermia.
- Provides crucial data for optimizing perfusion solutions in cardiac procedures.
- Highlights the vulnerability of specific microcirculatory components to different preservation methods.
Abstract:
The morphological analysis of the state of the heart during hypertermal perfusion with different conservants reveals clear dependence of the microcirculation and the activity of the heart upon the type of the conservant. Perfusion with a salt solution and hemodilution is accompanied by pronounced disorders in microcirculation and unsatisfactory parameters of the cardiac activity. Conservation with cryoprecipitated plasma is characterized by comparatively less microcirculatory disorders, but fails to give a reliable safety of the heart. When using medium 199, changes in microcirculation were found to be minimal and parameters of cardiac activity were satisfactory. In the complex of non-specific changes in microcirculatory vessels the maximum structural lability was revealed in blood capillaries and vessels of the postcapillary-venular link.