Related Experiment Video
Updated: Jul 25, 2026

05:22
Iris Fixation via External Pentagram Suturing
Published on: May 5, 2022
Slit-lamp needle revision for aqueous misdirection after trabeculectomy
Brian A Francis1, Richard M Wong, Don S Minckler
1The Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. bfrancis@hsc.usc.edu
Journal of Glaucoma
|July 26, 2002
Summary
A novel slit-lamp needle procedure effectively managed aqueous misdirection after trabeculectomy when other treatments failed. This technique offers a simple intervention to restore normal intraocular pressure and anterior chamber depth.
Area of Science:
- Ophthalmology
- Surgical Techniques
Background:
- Aqueous misdirection is a rare but serious complication following glaucoma surgery, such as trabeculectomy.
- Conventional medical and laser therapies are often insufficient for managing persistent aqueous misdirection.
Observation:
- Two patients developed refractory aqueous misdirection post-trabeculectomy.
- Transcorneal needling was performed to disrupt the anterior vitreous face and re-establish the anterior chamber.
Findings:
- Immediate resolution of clinical signs and normalization of intraocular pressure were observed in both cases.
- Intraocular pressure and anterior chamber depth remained stable during a 9-month follow-up period.
- One patient experienced a slow progression of pre-existing peripheral anterior synechia without affecting intraocular pressure.
Implications:
- Transcorneal needle disruption is a viable, minimally invasive option for managing complex aqueous misdirection.
- This procedure can help prevent corneal complications associated with prolonged flat anterior chambers.
- Further research may explore the long-term efficacy and applicability of this technique in a broader patient population.
Related Concept Videos
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...

