Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Signaling pathways in vascular development.

Janet Rossant1, Lorraine Howard

  • 1Samuel Lunenfeld Research Institute, Mount Sinai Hospital and Department of Molecular and Medical Genetics, University of Toronto, 600 University Avenue, Ontario, M5G 1X5, Canada. rossant@mshri.on.ca

Annual Review of Cell and Developmental Biology
|July 27, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human stem cell-based embryo models: innovation, ethics, and policy.

Human reproduction (Oxford, England)·2026
Same author

Enhancing rigor and reproducibility: Implementing STAR Methods and the ISSCR Standards Checklist at Stem Cell Reports.

Stem cell reports·2026
Same author

Stem cell-based embryo models: The 2021 ISSCR stem cell guidelines revisited.

Stem cell reports·2025
Same author

Author Correction: A comprehensive human embryo reference tool using single-cell RNA-sequencing data.

Nature methods·2025
Same author

Editorial.

Stem cell reports·2025
Same author

A comprehensive human embryo reference tool using single-cell RNA-sequencing data.

Nature methods·2024
Same journal

Hidden Messages in Extracellular Vesicles: Cross-Kingdom RNA Communication in Plant and Microbe Interactions.

Annual review of cell and developmental biology·2026
Same journal

mRNA-Scaffolded Cytoplasmic Compartments.

Annual review of cell and developmental biology·2026
Same journal

Developmental Programming of Human Kidney Function.

Annual review of cell and developmental biology·2026
Same journal

The Translation of Genetic Information in Neurodevelopment.

Annual review of cell and developmental biology·2026
Same journal

The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles.

Annual review of cell and developmental biology·2026
Same journal

Interstitial Spaces: A Basolateral Source of Structure and Signals.

Annual review of cell and developmental biology·2026
See all related articles

Understanding vascular development signaling pathways is crucial for both normal embryonic growth and treating diseases like cancer and heart disease. Research into these pathways offers new therapeutic targets for promoting or inhibiting blood vessel formation.

Area of Science:

  • Mammalian vascular biology
  • Embryonic development
  • Cellular signaling

Background:

  • The vasculature is a vital organ essential for nutrient and oxygen transport.
  • Vascular network formation is critical during embryonic development and for adult health.
  • Disruptions in vascular development can be lethal or lead to disease.

Purpose of the Study:

  • To understand the signaling pathways governing normal vascular development.
  • To identify therapeutic targets for diseases involving abnormal blood vessel formation.
  • To refine strategies for promoting or inhibiting angiogenesis.

Main Methods:

  • Review of existing literature on vascular development and signaling pathways.
  • Analysis of therapeutic interventions targeting angiogenesis.

Related Experiment Videos

  • Identification of key molecular mechanisms in vascular biology.

    • Main Results:

    • Signaling pathways of vascular development are implicated in both normal growth and disease.
    • Therapeutic strategies targeting angiogenesis are being developed for ischemia and cancer.
    • Existing studies have identified potential targets for intervention.

    Conclusions:

    • Further research into complex vascular signaling pathways is needed.
    • Enhanced understanding will refine therapeutic strategies for promoting new blood vessel formation (angiogenesis) in ischemic conditions.
    • Inhibiting tumor-induced angiogenesis is a key area of therapeutic interest.