Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hox genes and spinal cord development.

Ellen M Carpenter1

  • 1Department of Psychiatry, Mental Retardation Research Center, UCLA School of Medicine, 90024, USA. ecarpenter@mednet.ucla.edu

Developmental Neuroscience
|July 30, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hoxd10 Is Required Systemically for Secretory Activation in Lactation and Interacts Genetically with Hoxd9.

Journal of mammary gland biology and neoplasia·2020
Same author

Quantitative assessments reveal improved neuroscience engagement and learning through outreach.

Journal of neuroscience research·2019
Same author

Support for Undergraduate Neuroscience at the NSF and NIH.

Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience·2018
Same author

Reelin Deficiency Delays Mammary Tumor Growth and Metastatic Progression.

Journal of mammary gland biology and neoplasia·2017
Same author

Life science-based neuroscience education at large Western Public Universities.

Journal of neuroscience research·2016
Same author

Nonneuronal roles for the reelin signaling pathway.

Developmental dynamics : an official publication of the American Association of Anatomists·2016
Same journal

Microbiota-Based Interventions Differentially Rescue Gut and Social Behavior Phenotypes in Drosophila with Kdm5 Deficiency.

Developmental neuroscience·2026
Same journal

Maternal Infection Induces Neuronal Structure and Behavioural Alterations in Experimental Meningitis Rat Model.

Developmental neuroscience·2026
Same journal

Development of the Gut Microbiota throughout the First Year of Life and Its Association with Socio-Emotional Development into Childhood.

Developmental neuroscience·2026
Same journal

Intranasal Inhibition of Tropomyosin Receptor Kinase B Signaling during Early Postnatal Development Disrupts Growth and Sensorimotor Maturation in Neonatal Rodents.

Developmental neuroscience·2026
Same journal

Long-Term Consequences of Preterm Birth: A Lifespan Perspective.

Developmental neuroscience·2026
Same journal

From Womb to Weaning: Microbial Signals That Shape the Developing Brain.

Developmental neuroscience·2026
See all related articles

Hox genes are crucial for spinal cord development, guiding its regional patterning along the rostrocaudal axis. Their expression patterns and inactivation reveal their essential role in establishing distinct spinal cord segments.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • The spinal cord exhibits regional differentiation along its length, with specific cell types and projections defining distinct domains.
  • Transcription factors are key regulators of this complex developmental process.
  • Hox genes, a class of transcription factors, are known to play roles in patterning various embryonic structures.

Purpose of the Study:

  • To review the expression patterns of Hox genes in the developing spinal cord.
  • To examine the role of Hox genes in establishing rostrocaudal patterning of the spinal cord.
  • To understand how Hox gene activity influences the regional identity of spinal cord segments.

Main Methods:

  • Review of existing literature on Hox gene expression and function in spinal cord development.

Related Experiment Videos

  • Analysis of studies investigating the effects of Hox gene inactivation on spinal cord patterning.
  • Examination of the relationship between Hox gene expression domains and spinal cord regionalization.

    • Main Results:

    • Hox genes are expressed in overlapping rostrocaudal domains within the developing spinal cord.
    • Specific Hox gene groups, such as Ant-p/Ubx/Abd-D-related and Abd-D-related, show distinct expression patterns correlating with cervical and lumbar spinal cord regions, respectively.
    • Inactivation of Hox genes leads to observable changes in spinal cord patterning, confirming their functional importance.

    Conclusions:

    • Hox genes are essential regulators of spinal cord rostrocaudal patterning.
    • Their precise expression domains are critical for establishing the regional identity of the developing spinal cord.
    • Hox genes provide a molecular basis for the differentiation of spinal cord segments.