[Acute and subchronic toxicity of 8-hydroxyquinolone derivatives in combined application]

The toxicity of combined application of broxychinoline and broxaldin (5:1) was investigated in experiments on white mice and white rats. The presence of higher species specific sensitivity was observed in white mice. LD50 was determined by intraperitoneal application of 0.125 (0.085 + 0.182)/kg body weight on white mice: 0.213 (0.167 + 0.270)/kg body weight on white rats, and by subcutaneous application of more than 1.0/kg body weight on white mice. After a 30-day peroral application of the named combination on white rats at a daily dose of 0.1 kg body weight/24 h no disturbances in the physical state and in the microstructure of the inner organs were scored. The use of a dose of 0.24 kg/kg t/24 h resulted in necrobiotic changes in the kidneys. A trend toward shortening the time of blood clotting and of reducing the relative weight of the kidneys, spleen, lungs and heart is established.