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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Changes in the Appendicular Skeleton with Age01:09

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
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Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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Related Experiment Video

Updated: Jun 30, 2026

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
06:58

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position

Published on: August 17, 2017

Postmenopausal hormone use and skeletal fracture: does the size of the benefit decrease with increasing age?

Noel S Weiss1, Miriam M Treggiari

  • 1University of Washington, Seattle, Washington 98195, USA. nwiess@u.washington.edu

Obstetrics and Gynecology
|August 2, 2002
PubMed
Summary
This summary is machine-generated.

Hormone therapy offers skeletal benefits for postmenopausal women, regardless of age. Age should not be a factor when considering hormone therapy for fracture prevention.

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Last Updated: Jun 30, 2026

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Area of Science:

  • Gerontology
  • Endocrinology
  • Bone Health

Background:

  • A recent meta-analysis indicated a declining benefit of hormone use in reducing fractures with increasing age among postmenopausal women.
  • This finding raises questions about the adequacy of trial durations for assessing long-term hormone therapy effects in older populations.

Purpose of the Study:

  • To re-evaluate the impact of hormone therapy on skeletal fracture risk in postmenopausal women.
  • To determine if age should influence decisions regarding hormone therapy initiation or continuation for bone health.

Main Methods:

  • Review of randomized trials and nonrandomized studies on hormone use and fracture risk.
  • Analysis of bone mineral density as a surrogate endpoint in hormone therapy trials.

Main Results:

  • Existing randomized trials may be too short to fully assess long-term hormone therapy benefits in older postmenopausal women.
  • Both randomized trials (using bone mineral density) and nonrandomized studies suggest skeletal benefits from long-term hormone use, irrespective of age.
  • The absolute reduction in fracture risk with hormone use may be comparable or greater in older postmenopausal women than in younger ones, even if relative benefits decrease.

Conclusions:

  • Age should not be a primary consideration when evaluating the skeletal benefits of hormone therapy for postmenopausal women.
  • Healthcare providers and patients can consider hormone therapy for fracture prevention without age-related limitations on skeletal benefit.
  • Long-term hormone use demonstrates consistent skeletal advantages for postmenopausal women across different age groups.