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Total synthesis of amaryllidaceae alkaloid buflavine
Christophe Hoarau1, Axel Couture, Eric Deniau
1Laboratoire de Chimie Organique Physique, UPRESA 8009, Université des Sciences et Technologies de Lille, Bâtiment C3, DUSVA, 59655 Villeneuve d'Ascq Cedex, France.
The Journal of Organic Chemistry
|August 3, 2002
Abstract:
A concise synthesis of the amaryllidaceae alkaloid buflavine (1) and its regioisomer (2) involving sequential Meyers' biaryl coupling, enecarbamate formation, and hydrogenation followed by ultimate intramolecular reductive amination is presented.