Insights in the Synthesis of Imidazolones from Aldehydes, Isocyanides, or Oxazolines
Steven Frippiat1, Camille Sarre1, Christine Baudequin1
1Normandie University, COBRA, UMR 6014 et FR 3038, University of Rouen, INSA Rouen, CNRS, IRCOF, 1 rue Tesnière, 76821 Mont-Saint-Aignan Cedex, France.
Abstract:
α-Isocyanoacetamide derivatives were first converted to oxazolines under newly developed conditions. These oxazolines were used as precursors of α-isocyanoacrylamides, which could lead to various 2-arylated imidazolones. In addition, it was shown that both oxazolines and their precursors could efficiently lead to imidazolones unsubstituted at C2 in a very rapid, one-pot transformation, thus paving the way toward unprecedented routes to imidazolones, having a good tolerance to different substitution patterns.
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