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Related Experiment Videos

Psychopathology in the postgenomic era.

Robert Plomin1, Peter McGuffin

  • 1Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, DeCrespigny Park, London SE5 8AF, UK. r.plomin@iop.kcl.ac.uk

Annual Review of Psychology
|August 13, 2002
PubMed
Summary

Advances in genomics are revolutionizing the study of behavior and psychopathology. Future research will explore gene-behavior pathways at multiple levels, transforming psychological research and treatment.

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Area of Science:

  • Genetics
  • Psychology
  • Neuroscience

Background:

  • The postgenomic era is imminent, with complete human genome sequencing and variation identification.
  • Advances facilitate the identification of genes linked to psychopathology.
  • Progress has been slower than anticipated due to the polygenic nature of traits.

Purpose of the Study:

  • To highlight the potential of genomics in understanding behavior.
  • To emphasize the need for a multi-level approach (behavioral genomics and functional genomics) in genetic research.
  • To forecast the revolutionary impact of DNA on psychological research and treatment.

Main Methods:

  • Review of ongoing advances in genomic sequencing and variation identification.
  • Examination of current progress in identifying genes associated with psychopathology.

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  • Discussion of future research directions in functional genomics and behavioral genomics.

    • Main Results:

    • Replicated genetic linkages and associations are emerging for conditions like dementia, reading disability, and hyperactivity.
    • The complexity of genetic influences on behavior (polygenic traits) explains the slower-than-expected progress.
    • The integration of psychological, neuroscience, and molecular biological levels is crucial.

    Conclusions:

    • DNA sequencing and variation analysis will significantly advance the understanding of genetic influences on behavior.
    • Behavioral genomics offers a critical top-down perspective, complementing bottom-up molecular and neuroscience approaches.
    • The integration of genetic insights promises to revolutionize psychological research and clinical treatment in the coming decades.