Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cochlear and vestibular risk at high altitude].

K Mees1, M Suckfüll

  • 1Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke, Ludwig-Maximilians-Universität München. klaus.mees@hno.med.uni-muenchen.de

Laryngo- Rhino- Otologie
|August 13, 2002
PubMed
Summary

High altitude exposure causes physiological changes impacting the central nervous system, affecting hearing and balance. However, inner ear sensory cells remain unaffected by hypoxia or increased hematocrit.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Social network analysis in pigs: impacts of significant dyads on general network and centrality parameters.

Animal : an international journal of animal bioscience·2019
Same author

[Recurrent serious posttonsillectomy hemorrhage].

Laryngo- rhino- otologie·2010
Same author

[Rheopheresis as a successful second-line treatment for sudden hearing loss].

HNO·2010
Same author

[An unusual case of carotid arrosion bleeding].

HNO·2009
Same author

[Otorhinolaryngological aspects of high altitude medicine].

Laryngo- rhino- otologie·2008
Same author

WITHDRAWN: [Effects of atorvastatin on presbyacusis and tinnitus : A prospective, randomized, double-blind clinical trial.]

HNO·2007

Area of Science:

  • Physiology
  • Neuroscience
  • Otolaryngology

Background:

  • High altitude exposure induces physiological adaptations like hyperventilation and increased oxygen transport capacity via plasma diuresis.
  • Hemoconcentration, while increasing oxygen uptake, elevates blood viscosity, serum osmolality, and can impair blood flow.

Purpose of the Study:

  • To investigate the effects of high altitude conditions on central nervous system functions, specifically hearing and postural control.
  • To determine if cochlear and vestibular sensory cells are impaired by acute hypoxia, elevated hematocrit, or changes in serum osmolality.

Main Methods:

  • Utilized hypobaric chamber studies and existing data to analyze physiological responses to lowered oxygen pressure.
  • Assessed central nervous system functions including speech discrimination, directional hearing, and postural control.

Related Experiment Videos

  • Examined the impact of hematocrit levels and serum osmolality on cochlear and vestibular sensory cell function.

    • Main Results:

    • Elevated hematocrit levels and hypoxemia at high altitude may impair central nervous system functions, leading to deficits in speech discrimination, directional hearing, and postural control.
    • No evidence suggests that cochlear and vestibular sensory cells are affected by acute hypoxia or hematocrit levels up to 58%.
    • Increased serum osmolality or impaired osmoregulation did not interfere with outer hair cell function, preventing threshold shifts and hearing loss.

    Conclusions:

    • High altitude exposure impacts central nervous system functions related to sensory perception and motor control.
    • The inner ear's sensory cells (cochlear and vestibular) demonstrate resilience to the physiological stressors of acute hypoxia and hemoconcentration.