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Microencapsulation of semisolid ketoprofen/polymer microspheres
Giovanni Palmieri1, Giulia Bonacucina, Piera Di Martino
1Dipartimento di Scienze Chimiche, Università di Camerino, Via S. Agostino 1, 62032 Camerino, Italy. gianfilippo.palmieri@unicam.it
International Journal of Pharmaceutics
|August 15, 2002
Summary
Ketoprofen microspheres prepared at different temperatures showed improved compressibility for tablet formation. Tablets made from these microspheres effectively controlled drug release, with Eudragit RS formulations being most effective.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Controlled drug delivery systems aim to improve therapeutic efficacy and patient compliance.
- Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used for pain and inflammation management.
Purpose of the Study:
- To develop and characterize ketoprofen-loaded microspheres for controlled release.
- To evaluate the compressibility and tablet-forming properties of these microspheres.
- To assess the in vitro drug release from the prepared tablets.
Main Methods:
- Ketoprofen microspheres were prepared using emulsion/solvent evaporation at 15°C and 60°C.
- Semisolid microspheres formed at 60°C were microencapsulated via complex coacervation and spray-drying.
- Characterization included scanning electron microscopy, DSC, XRD, and in vitro dissolution.
- Tablet compressibility and drug release from tablets were evaluated.
Main Results:
- Microspheres prepared at both temperatures exhibited good compressibility, enabling tablet formation, unlike physical mixtures.
- Tablets containing ketoprofen microspheres demonstrated controlled drug release.
- Eudragit RS-containing tablets showed the most significant reduction in ketoprofen release rate.
Conclusions:
- Ketoprofen microspheres, particularly when formulated into tablets, offer a viable approach for controlled drug delivery.
- The preparation method and polymer choice significantly influence drug release characteristics.