Monte Carlo simulation of genome viability with paralog replacement
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Updated: Sep 30, 2026

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
Published on: August 3, 2018
Stanisław Cebrat1, Dietrich Stauffer
1Department of Genetics, Institute of Microbiology, University of Wrocław, Poland. cebrat@microb.uni.wroc.pl
Abstract:
Recent analyses of genome content have revealed that many single functions, even in haploid organisms, can be executed by more than one gene. As a result, experimental disruption of many individual genes does not exert lethal effects on the organism or even any visible change in the phenotype of the organism with a knockedout gene. Our analysis shows that such genetic redundancy allows for an appreciably higher mutation load in the genome simulations before the viability of the whole organism is destroyed.
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