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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
Challenges for the development of vaccines against Haemophilus influenzae and Neisseria meningitidis
Allan W Cripps1, Ruth Foxwell, Jennelle Kyd
1Gadi Research Centre for Health and Medical Sciences, University of Canberra, ACT 2601, Australia. allan.cripes@canberra.edu.au
Abstract:
The development of protein-polysaccharide conjugate vaccines has had a major impact on Haemophilus influenzae type b disease. The application of this technology to Neisseria meningitidis is also striking, particularly for serogroup C. However, significant challenges exist for the development of vaccines against non-typeable H. influenzae and against N. meningitidis serogroup B. Issues such as non-vaccine-strain replacement and correlates of protection need to be addressed as well as the longer-term implications of vaccination against what are essentially 'normal' microflora.
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