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Related Experiment Videos

Stochastic gene expression in a single cell.

Michael B Elowitz1, Arnold J Levine, Eric D Siggia

  • 1Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA. elowitm@rockefeller.edu

Science (New York, N.Y.)
|August 17, 2002
PubMed
Summary
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Cellular heterogeneity arises from gene expression noise. Both intrinsic and extrinsic noise significantly contribute to this variation, influenced by transcription rates and genetic factors.

Area of Science:

  • Microbiology
  • Systems Biology
  • Genetics

Background:

  • Clonal cell populations display significant phenotypic variation, crucial for biological processes.
  • This heterogeneity is hypothesized to stem from stochasticity, or noise, in gene expression.

Purpose of the Study:

  • To construct Escherichia coli strains for detecting and distinguishing the two primary sources of gene expression noise.
  • To quantitatively analyze the contributions of intrinsic and extrinsic noise to cellular variation.

Main Methods:

  • Development of specific Escherichia coli strains engineered for noise detection.
  • Experimental methods to differentiate between intrinsic noise (within a gene's expression) and extrinsic noise (from cellular environment fluctuations).

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Main Results:

  • Both intrinsic noise and extrinsic noise substantially contribute to the overall phenotypic variation in Escherichia coli.
  • Key factors such as transcription rate, regulatory dynamics, and genetic elements were identified as controllers of noise amplitude.

Conclusions:

  • Established a quantitative framework for modeling noise within genetic networks.
  • Demonstrated that low intracellular molecule counts fundamentally limit the precision of gene regulation.