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Fatal intoxication with omethoate.

M Pavlic1, A Haidekker, P Grubwieser

  • 1Institute of Legal Medicine, Leopold-Franzens-University of Innsbruck, Muellerstrasse 44, 6020 Innsbruck. marion.pavlic@uibk.ac.at

International Journal of Legal Medicine
|August 20, 2002
PubMed
Summary
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This case report details a fatal suicide involving omethoate insecticide ingestion. The toxicological analysis confirmed high levels of omethoate, leading to organ damage and reduced acetylcholinesterase (AChE) activity.

Area of Science:

  • Forensic Toxicology
  • Clinical Toxicology
  • Pesticide Poisoning

Background:

  • Organophosphate insecticides, like omethoate, are widely used but pose significant toxicity risks.
  • Suicide by pesticide ingestion is a global public health concern, particularly in agricultural communities.

Observation:

  • An 18-year-old male ingested an unknown quantity of omethoate, resulting in his death.
  • Autopsy revealed superficial wrist incisions, pulmonary edema, cardiac dilation, cerebral edema, and gastric mucosal changes.
  • A distinct chemical odor was noted from the body and organs.

Findings:

  • Toxicological analysis confirmed significant omethoate concentrations in blood, urine, bile, liver, kidneys, and gastric content.
  • Acetylcholinesterase (AChE) activity in peripheral blood serum was severely inhibited (<0.2% of normal).

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Implications:

  • This case highlights the lethal potential of omethoate, even in cases not previously documented in literature.
  • The findings underscore the importance of rapid toxicological screening and management in suspected organophosphate poisoning.
  • This report contributes to the understanding of omethoate's toxicokinetics and its fatal effects in humans.