[Impairement of the platelet lipid membrane composition in severe angina pectoris]

Investigation was performed on 54 patients with angina pectoris. The patients were divided into three groups. Group 1 included patients with angina pectoris of functional classes I-II, group 2 consisted of the patients with angina pectoris classes III-IV, and group 3--unstable angina pectoris. All the patients underwent investigation of content and ratio of some fraction of the phospholipids and cholesterol metabolites in the thrombocyte membranes. Results of investigation showed damage of phospholipid metabolism of the thrombocyte membranes. This is manifested by increased in content of lysophosphatidylcholine (LPCh), phosphatidylserine (PS) and phosphatidyletanolamine (PEA), decreased levels of sphingomyelin (SM) and phosphatidylcholine (PCh). The angina pectoris of effort of the functional classes III-IV and unstable angina pectoris were manifested by severe damage of lipid metabolism in the thrombocyte membranes.