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Updated: Sep 29, 2026
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
Published on: August 17, 2022
[Establishment of a new pig model for auxiliary partial orthotopic liver transplantation]
Chenghong Peng1, Liubin Shi, Shuyou Peng
1Department of Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
Objective:
To establish a new pig model for auxiliary partial orthotopic liver transplantation (APOLT).
Methods:
The liver of the donor was removed from its body. The left lobe of the liver was resected in vitro, and the right lobe was used as a graft. After the left lateral lobe of the recipient was resected, end-to-side anastomoses were performed between the suprahepatic inferior venae cavae of the donor and between the portal veins of the donor liver and those of recipient liver respectively. End-to-end anastomosis was performed between the hepatic artery of graft and the splenic artery of host. Outside drainage was placed in the donor's common bile duct.
Results:
Model of APOLT was established in 5 pigs with a success rate of 80%. The hemodynamics of the recipient was stable during and after operation.
Conclusion:
Significant decrease of congestion in portal vein and shortened blocking time were obtained because of the application of veno-venous bypass in vitro during complete vascular clamping. This new procedure, with such advantages as simple vessel processing, quality anastomosis, less postoperative hemorrhage and higher success rate, etc, effectively prevents ischemical reperfusion injury of the host liver and deserves to be spread.
