Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Suppression without inhibition in visual cortex.

Tobe C B Freeman1, Séverine Durand, Daniel C Kiper

  • 1Institute of Neuroinformatics, University of Zurich and Federal Institute of Technology, Winterthurerstrasse 190, Zurich, Switzerland.

Neuron
|August 27, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Map of spiking activity underlying change detection in the mouse visual system.

Cell·2026
Same author

Neuropixels Opto: combining high-resolution electrophysiology and optogenetics.

Nature methods·2026
Same author

Brainwide blood volume reflects opposing neural populations.

Nature·2026
Same author

Mapping the visual cortex with Zebra noise and wavelets.

Journal of vision·2026
Same author

Glutamate indicators with increased sensitivity and tailored deactivation rates.

Nature methods·2025
Same author

Map of spiking activity underlying change detection in the mouse visual system.

bioRxiv : the preprint server for biology·2025

Cross-orientation suppression in the visual cortex (V1) is unlikely to stem from within the cortex itself. Instead, subcortical mechanisms, potentially originating in the thalamus, appear to mediate this visual processing phenomenon.

Area of Science:

  • Neuroscience
  • Visual Processing
  • Sensory Systems

Background:

  • Neurons in the primary visual cortex (V1) are believed to receive inhibitory input from other V1 neurons tuned to various orientations.
  • Cross-orientation suppression, where V1 neuron responses are reduced by differently oriented visual stimuli, is a common observation.
  • This suppression has been traditionally attributed to intracortical inhibition within V1.

Purpose of the Study:

  • To investigate the origin of cross-orientation suppression in the primary visual cortex (V1).
  • To determine whether intracortical inhibition or subcortical mechanisms are responsible for suppression.
  • To explore the role of thalamic pathways in mediating visual suppression.

Main Methods:

  • Examined V1 neuron responses to visual stimuli with varying orientations and speeds.

Related Experiment Videos

  • Assessed the impact of rapid mask stimulus drift, which minimizes cortical responses.
  • Investigated the effect of hyperpolarization (via visual adaptation) on cortical neurons during mask presentation.

    • Main Results:

    • Cross-orientation suppression occurred even with mask stimuli drifting too rapidly to elicit significant cortical responses.
    • Suppression remained unaffected by hyperpolarization of cortical neurons, indicating it does not solely rely on cortical activity.
    • Thalamic neurons demonstrated some degree of suppression, suggesting a subcortical origin.

    Conclusions:

    • Intracortical inhibition is unlikely to be the primary driver of cross-orientation suppression in V1.
    • Subcortical structures, particularly the thalamus, likely play a significant role in mediating this visual suppression.
    • Mechanisms of suppression may involve thalamic processing and potentially the initial thalamocortical synapses.