Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synthetic cervical mucus formulation.

Bríd T Burruano1, Roger L Schnaare, Daniel Malamud

  • 1University of the Sciences in Philadelphia, Philadelphia, PA, USA.

Contraception
|September 3, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid diagnosis of Zika virus through saliva and urine by Loop-mediated isothermal amplification (LAMP).

Journal of oral microbiology·2018
Same author

Detection of Zika virus using reverse-transcription LAMP coupled with reverse dot blot analysis in saliva.

PloS one·2018
Same author

Zika Virus Specific Diagnostic Epitope Discovery.

Journal of visualized experiments : JoVE·2017
Same author

A Rapid, Self-confirming Assay for HIV: Simultaneous Detection of Anti-HIV Antibodies and Viral RNA.

Journal of AIDS & clinical research·2016
Same author

Rapid Point-of-Care Isothermal Amplification Assay for the Detection of Malaria without Nucleic Acid Purification.

Infectious diseases·2016
Same author

Saliva and viral infections.

Periodontology 2000·2015
Same journal

Reasons patients decide to replace or extend their long-acting reversible contraceptive before the full duration of pregnancy prevention: a qualitative study.

Contraception·2026
Same journal

Awareness of abortion medications by mail options among abortion patients at 6 clinics: Findings from a pilot study.

Contraception·2026
Same journal

A phase 1, randomized, open-label, single-dose relative bioavailability study of upper arm injection of depot medroxyprogesterone acetate comparing pharmacokinetics and hormone indicators of ovulation with anterior thigh and abdomen injection.

Contraception·2026
Same journal

Associations between pharmacy type, neighborhood disadvantage, and availability and accessibility of an over-the-counter oral contraceptive pill in three Michigan counties.

Contraception·2026
Same journal

Previous caesarean section and major complications during surgical abortion: a national multicentre case-control study.

Contraception·2026
Same journal

Quantification of residual levonorgestrel following extended use of the levonorgestrel 52 mg intrauterine device beyond 8 years.

Contraception·2026
See all related articles

A new synthetic cervical mucus formulation was created using guar gum and mucin. Its properties mimic natural mucus, with preparation methods being key to its performance.

Area of Science:

  • Biomaterials Science
  • Reproductive Biology
  • Chemical Engineering

Background:

  • Human cervical mucus plays a vital role in reproductive processes.
  • Accurate synthetic models of cervical mucus are needed for research and development.
  • Existing models may not fully replicate the complex rheological and chemical properties of native mucus.

Purpose of the Study:

  • To develop a synthetic formulation with properties similar to human cervical mucus.
  • To identify critical factors influencing the performance of the synthetic mucus formulation.

Main Methods:

  • A synthetic formulation was developed using guar gum crosslinked with borate ions and mucin.
  • The formulation was prepared in a pH 7.4, 0.1M phosphate buffer with a mixed preservative system.

Related Experiment Videos

  • Viscosity, spinnbarkeit, and pH were measured and compared to human cervical mucus values.

    • Main Results:

    • The synthetic formulation exhibited viscosity, spinnbarkeit, and pH comparable to human cervical mucus.
    • Guar gum source, mucin concentration, and preparation method were identified as critical parameters.
    • The formulation provides a reproducible and stable mimic of native cervical mucus.

    Conclusions:

    • A novel synthetic cervical mucus formulation has been successfully developed.
    • The formulation's performance is highly dependent on specific preparation variables.
    • This synthetic mucus offers a valuable tool for research in reproductive science and related fields.