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[L-forms of bacteria in the urine of patients with chronic pyelonephritis]
Abstract:
The authors present the data concerning the study of 200 patients suffering from chronic pyelonephritis; in 28 of these L-forms of bacteria were revealed in the urine. Of 46 L-cultures isolated from these patients 13 reversed into bacterial forms, 8 failed to reverse and were referred to the stable L-forms; the rest 25 L-cultures perished during the 8th--10th passage. This led to a supposition that the relapses and exacerbations of the infectious process in pyelonephritis were associated with the change of the L-forms into bacterial ones, and that the persistence of the L-forms in the kidney tissue promoted the maintenance of the chronic process.
Insights
Bacterial L-forms may cause chronic pyelonephritis relapses. Persistent L-forms in kidney tissue contribute to ongoing infection, suggesting a link between L-form dynamics and disease exacerbation.
Area of Science:
- Nephrology
- Microbiology
Context:
- Chronic pyelonephritis is a persistent kidney infection.
- Bacterial L-forms, which lack cell walls, are implicated in chronic infections.
Purpose:
- To investigate the role of bacterial L-forms in chronic pyelonephritis.
- To determine if L-forms can revert to bacterial forms in patients.
Summary:
- The study examined 200 patients with chronic pyelonephritis, finding bacterial L-forms in 28.
- Of 46 isolated L-cultures, 13 reverted to bacterial forms, 8 remained stable L-forms, and 25 perished.
- This suggests L-form reversion contributes to pyelonephritis relapses and exacerbations.
Impact:
- Findings suggest L-forms are a key factor in pyelonephritis chronicity.
- Understanding L-form behavior may lead to new therapeutic strategies for chronic kidney infections.