Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Engineering growing tissues.

Eben Alsberg1, Kenneth W Anderson, Amru Albeiruti

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Proceedings of the National Academy of Sciences of the United States of America
|September 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Driving emerging technology to clinical impact.

Journal of the American Dental Association (1939)·2026
Same author

Implantable living materials autonomously deliver therapeutics using contained engineered bacteria.

Science (New York, N.Y.)·2026
Same author

Feeder-free generation of functional dendritic cells from human pluripotent stem cells.

Journal for immunotherapy of cancer·2026
Same author

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Hemostatic Tough Adhesives seal tissue and control hemorrhage.

Nature communications·2026
Same author

Dental, Oral and Craniofacial Tissue Regeneration Consortium (DOCTRC): An infrastructure for accelerating regenerative therapies from discovery to clinical impact.

Journal of clinical and translational science·2026
Same journal

Chemotactic self-organization captures the dynamics of mammalian hair follicle patterning.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Tomographic imaging of superconducting order using particle-hole interference.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inhibitory potential of autologous neutralizing antibodies sets quantitative limits on the rebound-competent HIV-1 reservoir.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Inferring epidemiological parameters under an infectious phylogeography model with visitor dynamics.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Analytical modeling for suction cup designs for skin-interfaced wearable devices.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Improving cell-free metabolism through direct integration of artificial respiratory chains.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

Engineered tissues can be grown using biomaterials that provide growth signals, mimicking natural bone development. This approach enables the creation of functional, self-growing tissues for regenerative medicine applications.

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Tissue Engineering

Background:

  • Tissue engineering aims to replace or repair damaged tissues and organs.
  • Engineered tissues need to integrate with the host and adapt to the body's changing needs.
  • Current methods often lack the ability for sustained growth post-transplantation.

Purpose of the Study:

  • To engineer tissues capable of growth over time by incorporating growth stimulus signals into the biomaterial.
  • To investigate the potential of modified hydrogels to promote cell multiplication and tissue development.
  • To create a model for studying long bone growth and growth plate development.

Main Methods:

  • Co-transplantation of chondrocytes and osteoblasts onto hydrogels functionalized with an RGD peptide sequence.

Related Experiment Videos

  • Utilizing the biomaterial to deliver signals that promote cell multiplication and differentiation.
  • Analyzing the resulting tissue for mass, cellularity, and structural resemblance to native tissues.

    • Main Results:

    • Formation of new bone tissue exhibiting growth in mass and cellularity via endochondral ossification.
    • Transplanted cells organized into structures mimicking the morphology and function of growth plates.
    • Demonstrated a method for creating self-growing engineered tissues.

    Conclusions:

    • Biomaterial-mediated growth factor delivery can induce self-sustaining tissue regeneration.
    • This approach successfully engineered bone tissue that grows similarly to natural long bones.
    • The engineered growth plate model has potential applications in treating skeletal disorders and drug testing.