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Microarrays in pharmacogenomics--advances and future promise
Marina E Chicurel1, Dennise D Dalma-Weiszhausz
1Affymetrix, Inc., 3380 Central Expressway, Santa Clara, CA 95051, USA.
Pharmacogenomics
|September 12, 2002
Summary
Microarrays offer global views of genome sequence and gene activity, crucial for pharmacogenomics research. These tools aid in identifying response markers, discovering drug targets, and analyzing gene expression data.
Area of Science:
- Genomics
- Pharmacogenomics
- Molecular Biology
Background:
- Pharmacogenomics aims to personalize drug therapy by understanding genetic influences on drug response.
- Vast amounts of genomic data are required to achieve pharmacogenomics goals, including identifying predictive markers and novel drug targets.
- Microarrays provide a powerful platform for generating comprehensive gene expression and genotypic data.
Purpose of the Study:
- To review the evolving needs of pharmacogenomics research.
- To discuss how microarray technology addresses these demands.
- To examine the strengths, limitations, and future potential of microarrays in pharmacogenomics.
Main Methods:
- Review of scientific literature and databases (e.g., PharmGKB, dbSNP).
- Analysis of microarray applications in hypothesis-driven research and broad genomic surveys.
- Examination of microarray's role in clinical pharmacogenomics.
Main Results:
- Microarrays are central to thousands of peer-reviewed publications in pharmacogenomics.
- Microarrays contribute significantly to major biological databases.
- The technology supports both large-scale genomic analyses and focused, hypothesis-driven investigations.
Conclusions:
- Microarrays are indispensable tools for pharmacogenomics, providing essential gene expression and genotypic data.
- Their utility spans from fundamental research to potential clinical applications.
- Continued advancements in microarray technology will further enhance pharmacogenomics research and drug development.