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Systemic antibiotic therapy for acne: a review
1Division of Dermatology, Department of Medicine, University of Toronto, Ontario, Canada.
Abstract:
Acne is a multifactorial disease of the pilosebaceous unit in the skin. Four contributing pathogenic factors need to be elucidated and include excess sebum production, follicular hyperkeratinization, colonization of the pilosebaceous unit by Propionibacterium acnes, which is a gram positive anaerobic diphtheroid, and the release of inflammatory mediators into the follicle and dermis. One or more of these factors are targeted by each of the systemic therapies for this disease and its variant, including systemic antibiotic therapies, which will be reviewed here.
Insights
Acne is a skin condition caused by excess oil, clogged pores, and bacteria. Systemic therapies, including antibiotics, target these factors to treat acne vulgaris.
Area of Science:
- Dermatology
- Microbiology
Background:
- Acne vulgaris is a common skin condition affecting the pilosebaceous unit.
- Its pathogenesis involves multiple factors including excess sebum, follicular hyperkeratinization, Propionibacterium acnes colonization, and inflammation.
Purpose of the Study:
- To review systemic therapies for acne vulgaris.
- To discuss how these therapies target the multifactorial causes of acne.
Main Methods:
- Literature review of systemic acne treatments.
- Focus on systemic antibiotic therapies.
Main Results:
- Systemic therapies target key pathogenic factors of acne.
- Antibiotic therapies are a significant treatment modality.
Conclusions:
- Understanding the multifactorial nature of acne is crucial for effective treatment.
- Systemic antibiotics play a vital role in managing acne vulgaris.