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[Development of pre-hepatic portal hypertension of the rat]
M A Aller Reyero1, B Diéguez Fernández, M P Nava Hidalgo
1Facultad de Medicina, Universidad Complutense, Pza. Ramón y Cajal s/n, 28040 Madrid. maaller@med.ucm.es
Objective:
A long-term study of the prehepatic portal hypertension model by triple stenosing ligation of the portal vein in the rat.
Method:
A cluster analysis of the animals in the different evolutive stages of portal hypertension (1 1/2, 6, 12 and 14 months) has been carried out. This analysis has made it possible to identify three homogeneous groups (A, B and C) in relationship to the liver weight.
Results:
The animals with liver atrophy (group C) show a decrease of body, splenic and testicular weights as well as a higher development of the portosystemic collateral circulation in relation to the A and B groups.
Conclusion:
The percentage of animals belonging to the group C decrease progressively during the evolution of portal hypertension and those animals corresponding to the group A, in which is superior the liver weight, increase, while the B group does not change.
