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Studies with trimipramine on isolated kitten atria
Indian Journal of Physiology and Pharmacology
|October 1, 1975
Summary
Trimipramine increases kitten atrial contraction force dose-dependently. This effect, likely via noradrenaline, is blocked by reserpine or propranolol, suggesting its mechanism involves noradrenaline release or reuptake inhibition.
Area of Science:
- Pharmacology
- Cardiovascular Physiology
Background:
- Tricyclic antidepressants like trimipramine can affect cardiovascular function.
- The precise mechanisms underlying trimipramine's cardiac effects require further elucidation.
Purpose of the Study:
- To investigate the impact of varying trimipramine doses on isolated kitten atrial contractility.
- To explore the role of noradrenaline in mediating trimipramine's positive inotropic effects.
Main Methods:
- Isolated kitten atria were used to assess contractile force.
- Pretreatment with reserpine (in vivo) or propranolol (in vitro) was employed.
- The interaction between trimipramine and noradrenaline was evaluated.
Main Results:
- Trimipramine demonstrated a dose-dependent increase in atrial contraction force.
- Reserpine and propranolol pretreatment significantly inhibited trimipramine's positive inotropic effect.
- Trimipramine potentiated noradrenaline's positive inotropic action, an effect that diminished over time and led to noradrenaline antagonism.
Conclusions:
- Trimipramine's positive inotropic effect on kitten atria is likely mediated by the release and/or reuptake inhibition of endogenous noradrenaline.
- The findings suggest a complex interaction between trimipramine and the adrenergic system.