Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cell-cell adhesion and signalling.

Vania M M Braga1

  • 1Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, UK. v.braga@ic.ac.uk

Current Opinion in Cell Biology
|September 17, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional analyses and integrated mechanisms of cellular destruction by L-amino acid oxidase.

Cell death & disease·2025
Same author

Bothrops atrox venom: Biochemical properties and cellular phenotypes of three highly toxic classes of toxins.

Biochimica et biophysica acta. Proteins and proteomics·2023
Same author

Intrinsic cell rheology drives junction maturation.

Nature communications·2022
Same author

Rac1-PAK1 regulation of Rab11 cycling promotes junction destabilization.

The Journal of cell biology·2021
Same author

Development of a cell-based in vitro assay as a possible alternative for determining bothropic antivenom potency.

Toxicon : official journal of the International Society on Toxinology·2019
Same author

Cardiomyocyte-myofibroblast contact dynamism is modulated by connexin-43.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2019
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Rho small GTPases coordinate cell junction assembly and stability by interacting with cytoskeletal networks. This highlights an integrated view of cell-cell adhesion signaling pathways.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell-cell adhesion is crucial for tissue integrity and is regulated by complex signaling networks.
  • Rho small GTPases are key regulators of the actin cytoskeleton and cell adhesion.
  • Understanding the interplay between junctional complexes and cytoskeletal dynamics is essential.

Purpose of the Study:

  • To elucidate the role of Rho GTPase signaling pathways in coordinating cell junction assembly, stability, and function.
  • To investigate the interactions between adhesive complexes and the cortical cytoskeleton.
  • To explore the interplay between adherens junctions, Rho protein activation, and cytoskeletal filament dynamics.

Main Methods:

  • Signaling pathway analysis

Related Experiment Videos

  • Cell-based assays
  • Microscopy techniques
  • Biochemical assays

    • Main Results:

    • Rho GTPase signaling pathways were identified that regulate junction assembly, stability, and function.
    • Interactions between adhesive complexes and the cortical cytoskeleton were characterized.
    • A significant interplay was observed between adherens junctions, Rho protein activation, and the dynamics of microtubule, actin, and intermediate filaments.

    Conclusions:

    • Rho GTPase signaling plays a central role in integrating cell-cell adhesion with cytoskeletal organization.
    • The findings suggest a coordinated regulation of cell adhesion through the interplay of junctional complexes and cytoskeletal dynamics.
    • This research provides a more integrated perspective on signaling processes governing cell-cell adhesion.