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Fixed drug eruption to rofecoxib.
Susan T Nedorost1, Frances T Florentino, Anita C Gilliam
1Department of Dermatology, University Hospitals of Cleveland, Ohio 44106, USA. STN@po.CWRU.edu
Cutis
|September 18, 2002
Summary
Rofecoxib, a medication for painful periods, can cause a specific skin reaction known as a herpetiform fixed drug eruption. This reaction presented as a distinct red-brown lesion on the hand.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Dysmenorrhea is a common condition often treated with non-steroidal anti-inflammatory drugs (NSAIDs).
- Rofecoxib is a selective COX-2 inhibitor previously used for pain management.
Observation:
- A patient developed a unique skin eruption after taking rofecoxib for dysmenorrhea.
- The eruption manifested as a red-brown lesion on the dorsal hand.
Findings:
- The observed skin reaction exhibited characteristics of a herpetiform fixed drug eruption.
- Clinical and histological findings were consistent with this specific drug-induced dermatosis.
- The lips were predominantly involved in the eruption.
Implications:
- This case highlights a rare adverse drug reaction to rofecoxib.
- Understanding fixed drug eruptions is crucial for patient safety and medication management.
- Clinicians should be aware of potential dermatological side effects of NSAIDs.