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Related Experiment Videos

Neuromaturation of multiples.

Marilee C Allen1, Pamela K Donohue

  • 1The Eudowood Division of Neonatology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287-3200, USA. mcallen@jhmi.edu

Seminars in Neonatology : SN
|September 18, 2002
PubMed
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Multiple gestation infants face similar risks as singletons, with no benefit to early delivery before 30 weeks unless medically indicated. Optimal delivery timing for multiples balances fetal lung maturity against risks of intrauterine death.

Area of Science:

  • Neonatalogy
  • Maternal-Fetal Medicine
  • Perinatology

Background:

  • Preterm birth etiology and infant maturation dictate survival and complications.
  • Multiple gestation increases preterm birth risk, but its impact on maturation and complications is debated due to confounding factors.

Purpose of the Study:

  • To evaluate the influence of multiple gestation on preterm infant outcomes and determine optimal delivery timing.
  • To compare neonatal mortality, complications, and neuromaturation in preterm multiples versus singletons.

Main Methods:

  • Comparative analysis of outcomes for very low birthweight preterm multiples and singletons.
  • Assessment of survival rates and complications based on gestational age and fetal status.

Main Results:

Related Experiment Videos

  • Preterm multiples and singletons of similar gestational age exhibit comparable neonatal mortality, complications, and neuromaturation.
  • No survival advantage exists for delivering multiples before 30 weeks gestation, barring fetal decompensation.
  • Survival improves for near-term multiples as intrauterine growth slows and fetal maturation accelerates.

Conclusions:

  • Delivery of multiples should occur upon confirmation of fetal lung maturity.
  • Elective delivery is suggested for twins between 35-38 weeks and triplets between 33-35 weeks gestation, considering fetal lung maturity and risks of intrauterine death.