[Convoluted cell lymphoblastic lymphoma (author's transl)].

Area of Science:

• Oncology
• Hematology
• Pathology

Background:

• Non-Hodgkin's lymphomas encompass a heterogeneous group of lymphoid malignancies.
• A distinct entity, lymphoblastic convoluted-cell lymphoma, has been identified, often of thymic origin.
• Accurate classification is crucial for diagnosis and treatment.

Purpose of the Study:

• To describe the morphologic and radiological features of lymphoblastic convoluted-cell lymphoma.
• To analyze the clinical presentation, anatomical distribution, and outcomes of affected patients.
• To support the classification of this entity as a distinct type of malignant lymphoma.

Main Methods:

• Morphological analysis of lymph node biopsies.
• Radiological assessment including imaging and lymphography.
• Clinical data review and patient follow-up.

Main Results:

• Nine cases were diagnosed, predominantly in males (6/9) aged 6-54 years.
• Characteristic histological findings include convoluted nuclei and cribriform structures.
• Extranodal involvement, bone marrow, and peripheral blood invasion were common; a thymic mass was frequently observed.
• Short-term follow-up indicated poor prognosis for some patients.

Conclusions:

• The distinct cellular morphology aids in diagnosing lymphoblastic convoluted-cell lymphoma.
• This entity warrants recognition as an autonomous type within lymphoma classifications.
• Further research may refine diagnostic criteria and therapeutic strategies.