A clinical study on injectable contraceptive Noristerat

Area of Science:

• Reproductive Health
• Clinical Pharmacology
• Contraception

Background:

• Injectable contraceptives offer long-acting reversible contraception.
• Norethisterone enanthate is a progestogen-only injectable contraceptive.
• Understanding user adherence and side effect profiles is crucial for effective family planning programs.

Purpose of the Study:

• To evaluate the efficacy and acceptability of Noristerat (norethisterone enanthate) as an injectable contraceptive.
• To assess continuation rates, side effects, and pregnancy rates in users.
• To identify reasons for discontinuation.

Main Methods:

• A clinical study involving 382 subjects utilizing Noristerat.
• Data collection on subject demographics, injection timing, continuation rates, weight changes, blood pressure, menstrual patterns, and pregnancy.
• Analysis of reasons for discontinuation.

Main Results:

• High continuation rates observed, with approximately 75% returning for the second injection.
• Weight gain was more common than weight loss; no significant blood pressure changes.
• 52.2% reported normal menstrual patterns; 12.7% experienced amenorrhea; 15% had other menstrual disturbances.
• Only one pregnancy occurred among the 382 subjects.

Conclusions:

• Noristerat demonstrates high efficacy and continuation rates for injectable contraception.
• Menstrual abnormalities were the primary reason for discontinuation among interviewed subjects.
• Noristerat is a safe and effective contraceptive option with a favorable side effect profile.