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Updated: Sep 29, 2026

Rearing and Double-stranded RNA-mediated Gene Knockdown in the Hide Beetle, Dermestes maculatus
Published on: December 28, 2016
Pipsqueak and GAGA factor act in concert as partners at homeotic and many other loci
Alexander Schwendemann1, Michael Lehmann
1Institut für Biologie, Genetik, Freie Universität Berlin, Arnimallee 7, D-14195 Berlin, Germany.
Abstract:
The Drosophila GAGA factor (GAF) controls transcription and other chromosome functions by altering chromatin structure. We found that a second GAGA-binding protein of Drosophila, Pipsqueak (Psq), can directly bind to GAF and is associated with GAF in vivo. Genetic interaction studies provide evidence that Psq and GAF act together in the transcriptional activation and silencing of homeotic genes. A complete colocalization of Psq and GAF on polytene interphase chromosomes and mitotic chromosomes suggests that the two proteins cooperate as general partners not only at homeotic loci, but also at hundreds of other chromosomal sites.
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