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Local antimicrobial therapy after initial periodontal treatment
Giovanni E Salvi1, Andrea Mombelli, Lisa Mayfield
1University of Berne, School of Dental Medicine, Berne, Switzerland. SALVI@zmk.unibe.ch
Journal of Clinical Periodontology
|September 26, 2002
Summary
Atridox demonstrated superior probing attachment level (PAL) gain compared to Elyzol in periodontal therapy. All three sustained-release devices significantly reduced pocket probing depths (PPD).
Area of Science:
- Periodontology
- Biomaterials Science
- Clinical Trials
Background:
- Periodontal disease management often requires adjunctive therapies post-initial treatment.
- Biodegradable sustained-release polymers offer localized drug delivery for periodontal pockets.
Purpose of the Study:
- To compare the clinical and microbiological outcomes of three sustained-release biodegradable polymers (Atridox, Elyzol Dental Gel, PerioChip) delivered into periodontal pockets after initial therapy.
Main Methods:
- A single-blind, randomized clinical trial involving 47 patients with moderate to severe periodontitis.
- Clinical parameters (Plaque Index, Bleeding on Probing, Pocket Probing Depths, Probing Attachment Levels) and microbiological samples were assessed over 18 weeks.
- Patients received initial periodontal therapy followed by random assignment to one of the three polymer treatments.
Main Results:
- Atridox showed a significantly greater mean Probing Attachment Level (PAL) gain (0.33 mm) compared to Elyzol Dental Gel (0.03 mm) (p=0.03).
- PerioChip's PAL gain (0.16 mm) was not significantly different from Atridox.
- All three devices resulted in a significant reduction in Pocket Probing Depths (PPD).
Conclusions:
- Atridox demonstrated a statistically significant gain in mean PAL compared to Elyzol.
- All tested biodegradable sustained-release devices led to a significant reduction in PPD.
- These findings support the use of sustained-release polymers as an adjunct to initial periodontal therapy.