Related Experiment Video
Updated: Aug 18, 2026

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
Published on: June 25, 2010
Chemical analytic approaches to the definition of uremic toxins
Abstract:
In this preliminary research we have started a systematic study of substances present in uremic but non in normal serum. Methylguanidine has been examined by the new single method of ion pair extraction and has been found in higher concentration in uremic plasma than in normal, but in lower concentration than previously described with less selective method and used in experimental animal intoxication. We did not find a correlation of Methylguanidine concentration and uremic symptoms and complications as pericarditis, neuropathy and uremic coma. Using the high spead gel filtration method comparative analyses of uremic and normal fluids and many substances have been registered a 9 peak serie. Peak 7 seem to be the most interesting. It is less prominent in normal plasma, increases in uremic patients and decreases after dietary treatment, peritoneal dialysis and hemodialysis. Furthermore it is formed by middle molecular weight substances (approximately 1300).
More Related Videos
08:41Integration of Miniaturized Solid Phase Extraction and LC-MS/MS Detection of 3-Nitrotyrosine in Human Urine for Clinical Applications
Published on: July 14, 2017
06:32Development of Human Renal Tubular Epithelial Cell Primary Cultures in Monolayers and Three-Dimensional Conditions
Published on: June 13, 2025
Related Concept Videos
Drug Elimination by Renal Route: Tubular Reabsorption
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Dialysis
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Urine Studies I: Urinalysis
Serum Studies: Renal Function Tests