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Related Experiment Videos

Parental modifiers, antisense transcripts and loss of imprinting.

Jon F Wilkins1, David Haig

  • 1Program in Biophysics, Harvard University, Cambridge, MA 02138, USA. jfwilkin@fas.harvard.edu

Proceedings. Biological Sciences
|September 28, 2002
PubMed
Summary

Genomic imprinting, or parent-specific gene expression, is less stable at demand-suppressing loci than demand-enhancing loci due to the evolution of trans-acting modifiers influencing gene expression.

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Area of Science:

  • Evolutionary biology
  • Genetics
  • Molecular biology

Background:

  • Genomic imprinting explains parent-specific gene expression as an evolutionary conflict over offspring resource demand.
  • Previous models predicted silencing of maternal alleles at demand-enhancing loci and paternal alleles at demand-suppressing loci.

Purpose of the Study:

  • To investigate the evolutionary stability of genomic imprinting.
  • To examine the role of trans-acting modifiers in parent-offspring conflict over gene expression.

Main Methods:

  • Theoretical modeling of evolutionary game theory.
  • Analysis of allele silencing and reactivation dynamics.

Main Results:

  • Trans-acting modifiers can be selected to reactivate silent paternal alleles at demand-suppressing loci.

Related Experiment Videos

  • Modifiers are not selected to reactivate silent maternal alleles at demand-enhancing loci.

    • Conclusions:

    • Imprinting at demand-suppressing loci is less evolutionarily stable than at demand-enhancing loci.
    • The evolution of modifiers impacts the stability of imprinted gene expression patterns.