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Bladder augmentation in dogs using the tissue capsule formed around a perivesical tissue expander
Brady R Walker1, Michael P Gardner, John M Gatti
1Division of Urology, University of Utah, Salt Lake City, USA.
The Journal of Urology
|September 28, 2002
Summary
Bladder augmentation using a tissue expander capsule is feasible in dogs, improving bladder capacity and compliance. However, osseous metaplasia may cause anastomotic narrowing, limiting cystography.
Area of Science:
- Urology
- Regenerative Medicine
- Biomaterials Science
Background:
- Enterocystoplasty improves bladder storage but has significant morbidity.
- Exploring novel bladder augmentation techniques is crucial for patient outcomes.
- Tissue expander-derived capsules offer a potential alternative biomaterial.
Purpose of the Study:
- To evaluate the feasibility of using perivesical tissue expander capsules for bladder augmentation in a canine model.
- To assess the functional and histological changes following this novel augmentation procedure.
Main Methods:
- Six mongrel dogs underwent perivesical tissue expander placement.
- Capsules formed around expanders were harvested and anastomosed to the bladder.
- Videourodynamics, serum electrolyte analysis, and histological evaluations were performed.
Main Results:
- Bladder augmentation using the fibrous capsule was technically achievable in dogs.
- Improved bladder capacity and compliance were observed, though variable.
- Histology revealed urothelial and smooth muscle ingrowth, but also osseous metaplasia at the anastomosis.
Conclusions:
- Perivesical tissue expander capsules are a viable option for bladder augmentation.
- The technique shows promise for improving bladder function.
- Osseous metaplasia presents a potential challenge for anastomotic patency and imaging.