Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluconazole-carbamazepine interaction.

Christopher K Finch1, Christie A Green, Timothy H Self

  • 1Department of Clinical Pharmacy, University of Tennessee Health Science Center, Memphis 38163, USA.

Southern Medical Journal
|October 3, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Projecting financial sustainability for clinical pharmacy services: An implementation science brief report.

Journal of the American Pharmacists Association : JAPhA·2025
Same author

Faculty experiences developing and directing a novel multi-campus medication therapy management introductory pharmacy practice experience.

Currents in pharmacy teaching & learning·2025
Same author

The association between comprehensive medication review and medication adherence among medicare beneficiaries with chronic obstructive pulmonary disease.

Exploratory research in clinical and social pharmacy·2024
Same author

Effects of Medicare Part D medication therapy management on racial/ethnic disparities in adherence to antidementia medications among patients with Alzheimer's disease and related dementias: An observational study.

Exploratory research in clinical and social pharmacy·2024
Same author

Leading beyond the Script: A Cross-Sectional Study Exploring Preparedness of Pharmacy Academic Administrators.

Pharmacy (Basel, Switzerland)·2024
Same author

Racial/ethnic disparities in the enrollment of Medication Therapy Management programs among Medicare beneficiaries with Alzheimer's disease and related dementias.

Current medical research and opinion·2022
Same journal

The Five Essential Concepts of Developmental Medicine: A Medical Paradigm for People with Developmental Disabilities.

Southern medical journal·2026
Same journal

α-Gal Syndrome in the South: Why We Need Treatment Trials, Not Just Tick Prevention.

Southern medical journal·2026
Same journal

Association between Main Pancreatic Duct Size, Comorbidities, and Fistula Formation after Whipple Procedure for Pancreatic Cancer.

Southern medical journal·2026
Same journal

Impact of Temperature Variation on Patients with Acute Severe Asthma.

Southern medical journal·2026
Same journal

Assessing the Accuracy and Reliability of ChatGPT-4 to Answer Clinical EHR Messages in Sports Medicine.

Southern medical journal·2026
Same journal

Diagnostic Utility and Clinical Implications of Inpatient Fecal Occult Blood Testing.

Southern medical journal·2026
See all related articles

Fluconazole, an antifungal, can increase carbamazepine levels in the blood. This drug interaction may occur because fluconazole inhibits the metabolism of carbamazepine.

Area of Science:

  • Pharmacology
  • Drug Metabolism
  • Clinical Toxicology

Background:

  • Carbamazepine is an anticonvulsant and mood-stabilizing drug.
  • Fluconazole is a widely used antifungal agent.
  • Drug-drug interactions involving cytochrome P450 enzymes are clinically significant.

Observation:

  • A patient exhibited elevated serum carbamazepine concentrations during concurrent administration of fluconazole (400 mg/day).
  • Serial carbamazepine levels were monitored before, during, and after fluconazole treatment.

Findings:

  • Fluconazole is a known inhibitor of the cytochrome P450 enzyme system.
  • The observed increase in carbamazepine levels suggests fluconazole inhibits carbamazepine metabolism.
  • This interaction highlights the potential for altered drug pharmacokinetics.

Related Experiment Videos

Implications:

  • Clinicians should monitor carbamazepine levels when co-prescribing with fluconazole.
  • Dosage adjustments may be necessary to prevent carbamazepine toxicity.
  • Understanding drug interactions is crucial for patient safety and effective treatment.