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Acid-accelerated DNA-cleaving activities of antitumor antibiotic varacin
Alex H F Lee1, Albert S C Chan, Tianhu Li
1Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.
Chemical Communications (Cambridge, England)
|October 3, 2002
Abstract:
It is demonstrated in this report that the authentic molecular structure of antibiotic varacin is capable of causing DNA-cleavage with high efficiency in the presence of thiols. In addition, it is found that the DNA-cleaving activity by varacin is apparently promoted by its acidic environments.