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Corticosteroids and central serous chorioretinopathy.
Cynthia A Carvalho-Recchia1, Lawrence A Yannuzzi, Silvana Negrão
1LuEsther T. Mertz Retinal Research Department, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021, USA.
Ophthalmology
|October 3, 2002
Summary
Corticosteroid use is a significant risk factor for central serous chorioretinopathy (CSC). This study found a strong association between steroid exposure, including various administration forms and hypercortisolism, and the development of CSC.
Area of Science:
- Ophthalmology
- Endocrinology
Background:
- Central serous chorioretinopathy (CSC) is a condition affecting vision.
- The role of corticosteroid use in CSC pathogenesis requires further investigation.
Purpose of the Study:
- To investigate the relationship between corticosteroid use and central serous chorioretinopathy (CSC).
- To identify corticosteroids as a potential risk factor for CSC development.
Main Methods:
- A prospective, case-controlled study design was employed.
- Patients with acute CSC and matched controls were recruited.
- Clinical history, fundus examination, and fluorescein angiography were utilized.
Main Results:
- 52% of CSC patients reported exogenous steroid use (oral, IV, intranasal, intraarticular).
- 2% of CSC patients had endogenous hypercortisolism (Cushing's syndrome).
- Steroid use was significantly higher in CSC patients (52%) compared to controls (18%, P < 0.0001).
Conclusions:
- Corticosteroid use is a significant risk factor for acute, exudative CSC.
- Hypercortisolism is implicated in the pathogenesis of CSC.
- Patients requiring corticosteroids should be informed about the risk of developing CSC.