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Hemostatic changes in active pulmonary tuberculosis
1Department of Hematology and Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
Summary
Pulmonary tuberculosis (PTB) patients exhibit a hypercoagulable state due to hemostatic disturbances like low antithrombin III and protein C. Treatment improves these factors, reducing thrombosis risk.
Area of Science:
- Hematology
- Infectious Diseases
- Pulmonology
Background:
- Severe pulmonary tuberculosis (PTB) can be complicated by deep vein thrombosis (DVT).
- Hemostatic disturbances may predispose PTB patients to venous thrombosis.
Purpose of the Study:
- To investigate hemostatic disturbances in patients with active PTB.
- To identify predisposing factors for venous thrombosis in PTB.
Main Methods:
- Coagulation and platelet function tests were performed on 45 PTB patients and 20 healthy controls.
- Tests were conducted before therapy and compared with results at 30 days of treatment.
Main Results:
- PTB patients showed anemia, thrombocytosis, elevated fibrinogen and factor VIII, and depressed antithrombin III (AT III) and protein C (PC) levels.
- Platelet aggregation was increased, indicating platelet activation.
- Treatment improved anemia, thrombocytosis, and normalized fibrinogen, factor VIII, PC, and AT III levels.
Conclusions:
- Decreased AT III and PC, elevated fibrinogen, and increased platelet aggregation contribute to a hypercoagulable state in PTB.
- These hemostatic abnormalities improve with PTB treatment.
- No activated protein C resistance was observed, and DVT was not detected during follow-up.