Related Experiment Videos
Recent advances in topoisomerase I-targeting agents, camptothecin analogues
1Life Science Research Center, SK Chemicals, 600 Jungja-Dong, Changan-Ku, Suwon-Si, Kyungki-Do 440-745, Korea. dkkim@skchemicals.com
Mini Reviews in Medicinal Chemistry
|October 9, 2002
Abstract:
The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.