Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centriole duplication: centrin in on answers?

Luke M Rice1, David A Agard

  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143, USA.

Current Biology : CB
|October 10, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization Standard for <i>In-situ</i> Cryo-electron Tomography.

bioRxiv : the preprint server for biology·2026
Same author

AreTomoLive: automated reconstruction of comprehensively corrected and denoised cryo-electron tomograms in real time and at high throughput.

Nature methods·2026
Same author

Evaluating the Volta phase plate for improved tomogram alignment in cryo-electron tomography.

IUCrJ·2026
Same author

Dimeric Cin8 motors have an inherent plus-end bias and weak interhead coordination.

Biophysical journal·2026
Same author

Cathepsin C-Catalyzed Ligation Generates Intralysosomal Amyloid Fibrils from Dipeptide Esters.

bioRxiv : the preprint server for biology·2026
Same author

Single-molecule microtubule dynamics measurements reveal an intermediate state and clarify the role of nucleotide.

Nature communications·2025
Same journal

Hunting ecology predicts eye arrangements in the modular visual system of spiders.

Current biology : CB·2026
Same journal

Sub-second fluctuations between top-down and bottom-up modes distinguish diverse human brain states.

Current biology : CB·2026
Same journal

Queen bees offload pesticide burden to eggs when social buffering is overwhelmed.

Current biology : CB·2026
Same journal

Pitch selectivity in ferret auditory cortex.

Current biology : CB·2026
Same journal

A cell size-dependent competition between geometry and polarity governs nuclear and spindle positioning in early embryos.

Current biology : CB·2026
Same journal

Trophic cascades drive sustainability in the agricultural heritage rice-fish coculture system.

Current biology : CB·2026
See all related articles

Centriole duplication is blocked when the protein centrin-2 is reduced in HeLa cells. This essential finding in cell biology may lead to cell death, highlighting centrin-2

Area of Science:

  • Cell Biology
  • Centrosome Biology
  • Molecular Biology

Background:

  • Centrioles are crucial for cell division and organization.
  • The precise functions of many centriolar proteins are not fully understood.

Purpose of the Study:

  • To investigate the role of the centriolar protein centrin-2 in centriole duplication.
  • To determine the consequences of reduced centrin-2 levels in cellular function.

Main Methods:

  • Utilized HeLa cells for experimental manipulation.
  • Reduced the levels of centrin-2 protein within the cells.

Main Results:

  • A significant reduction in centrin-2 levels effectively blocked centriole duplication.
  • The observed blockage of centriole duplication led to subsequent cell death.

Related Experiment Videos

Conclusions:

  • Centrin-2 plays a critical role in the duplication process of centrioles.
  • Disrupting centrin-2 levels has severe implications for cell viability.