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Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone) compounds
Yousef Al-Abed1, Larisa Dubrovsky, Bela Ruzsicska
1Laboratory of Medicinal Chemistry, North Shore-LIJ Research Institute, 350 Community Drive, Manhasset, NY, 11030, USA. yalabed@nshs.edu
Bioorganic & Medicinal Chemistry Letters
|October 10, 2002
Abstract:
Arylene bis(methylketone) compounds specifically block nuclear translocation of the HIV-1 pre-integration complex by forming Schiff-base adducts with contiguous lysines within nuclear localization signal.