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Acute interstitial nephritis due to nicergoline (Sermion).
Mi Jeong Kim1, Jae Hyuck Chang, Suk Kyeong Lee
1Department of Internal Medicine and Clinical Pathology, Kangnam St. Mary's Hospital, Catholic University of Korea, Seoul, Korea.
Nephron
|October 10, 2002
Summary
This study details a rare case of acute interstitial nephritis (AIN) caused by the medication nicergoline. Prompt diagnosis and treatment, including drug withdrawal, led to complete kidney function recovery.
Area of Science:
- Nephrology
- Clinical Pharmacology
- Internal Medicine
Background:
- Acute interstitial nephritis (AIN) is an important cause of intrinsic renal failure.
- Drug-induced AIN is often underdiagnosed, necessitating increased awareness.
- Nicergoline is a medication used for cerebrovascular and peripheral vascular disorders.
Observation:
- A 50-year-old male presented with fever and acute renal failure.
- The patient had been taking nicergoline and bendazac lysine for retinal vein occlusion.
- Symptoms included fever, skin rash, arthralgia, and laboratory findings of eosinophilia and renal failure.
Findings:
- Renal biopsy confirmed acute interstitial nephritis.
- A lymphocyte transformation test showed a positive reaction to nicergoline.
- This is the first reported case of nicergoline-associated AIN.
Implications:
- Nicergoline should be considered as a potential cause of drug-induced AIN.
- Early identification and withdrawal of the offending drug are crucial for renal recovery.
- This case highlights the importance of thorough medication history in patients with unexplained renal failure.