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Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry
Jesus R Guajardo1, Lauren M Plotnick, Jennifer M Fende
1Division of Allergy and Immunology, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
The Journal of Pediatrics
|October 16, 2002
Summary
Eosinophil-associated gastrointestinal disorders often coexist with atopic conditions and food sensitivities, suggesting strong genetic and allergic links. This research highlights the importance of these factors in understanding these complex conditions.
Area of Science:
- Gastroenterology
- Immunology
- Genetics
Background:
- Eosinophil-associated gastrointestinal disorders (EA-GI) are increasingly recognized.
- Understanding their underlying causes and associated conditions is crucial.
Purpose of the Study:
- To identify distinguishing features of EA-GI using a novel data collection method.
- To explore the genetic and allergic components of EA-GI.
Main Methods:
- A world wide web database was utilized to collect patient-reported features of EA-GI.
- Data analysis focused on coexisting conditions, sensitization, and family history.
Main Results:
- 80% of participants had coexisting atopic disease.
- 62% reported food sensitization.
- 16% had a family history of similar disorders.
Conclusions:
- EA-GI disorders exhibit significant genetic and allergic influences.
- The internet is an effective tool for gathering patient data on rare disorders.