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Gamma Knife radiosurgery of brainstem gliomas
Acta Neurochirurgica. Supplement
|October 16, 2002
Summary
Gamma Knife radiosurgery (GKRS) effectively treated brainstem gliomas in 21 patients, showing promising tumor control and improved neurological function. This radiosurgery approach offers a valuable option for managing these challenging brain tumors.
Area of Science:
- Neurosurgery
- Radiation Oncology
- Oncology
Background:
- Brainstem gliomas are challenging tumors requiring effective treatment modalities.
- Gamma Knife radiosurgery (GKRS) has emerged as a potential therapeutic option.
Purpose of the Study:
- To evaluate the efficacy and outcomes of Gamma Knife radiosurgery (GKRS) for brainstem gliomas.
- To assess tumor control, functional outcomes, and survival rates in patients treated with GKRS.
Main Methods:
- Retrospective analysis of 21 patients with histologically confirmed brainstem gliomas treated with GKRS between 1992 and 1999.
- Median GKRS dose of 12 Gy applied to the tumor margin.
- Neuroimaging follow-up (MR, CT) and clinical assessment of outcomes.
Main Results:
- Tumor progression observed in 2 patients, stable disease in 10, and regression in 3.
- Neurological state improved in 5 patients.
- Nine patients died from causes unrelated to radiosurgery; median survival was 20.7 months.
Conclusions:
- Gamma Knife radiosurgery (GKRS) is an effective treatment for brainstem gliomas.
- GKRS provides satisfying tumor control and functional outcomes.
- GKRS represents a valuable therapeutic option for brainstem glioma management.