Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Membrane fusion.

Reinhard Jahn1, Helmut Grubmüller

  • 1Department of Neurobiology, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 37077, Göttingen, Germany. rjahn@gwdg.de

Current Opinion in Cell Biology
|October 18, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A minimal chemo-mechanical Markov model for rotary catalysis of F<sub>1</sub>-ATPase.

Nature communications·2026
Same author

Hierarchical multi-timescale structural dynamics of the disordered N-terminal of p53.

Nature communications·2026
Same author

Diverse mechanisms of translation arrest by a Clostridia ribosome stalling peptide CliM.

Nature communications·2026
Same author

A versatile nanobody platform for live and super-resolution imaging of synaptic vesicle dynamics and plasticity in rodent and human neurons.

Journal of nanobiotechnology·2026
Same author

Bimodal Peptide Collision Cross Section Distribution Reflects Two Stable Conformations in the Gas Phase.

Journal of proteome research·2026
Same author

Improving Conformational Ensembles of Folded Proteins in Go̅Martini.

Journal of chemical theory and computation·2026
Same journal

Mechanosensing in immune cells: Implications for migration and beyond.

Current opinion in cell biology·2026
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
See all related articles

Biological membrane fusion relies on physical principles. Research explores whether lipid physics or protein-lipid interactions drive fusion, with ongoing investigations into SNARE proteins and advanced bilayer fusion models.

Area of Science:

  • Biophysics
  • Cell Biology
  • Molecular Biology

Background:

  • Membrane fusion is a fundamental biological process essential for cellular functions.
  • The precise mechanisms governing the transition states of membrane fusion remain incompletely understood.
  • Existing models often simplify the complex interplay between lipid dynamics and protein involvement.

Purpose of the Study:

  • To investigate the relative contributions of lipid physics and protein-lipid interactions in determining membrane fusion transition states.
  • To review and integrate recent advancements in the physical description of bilayer fusion.
  • To highlight the role of SNARE proteins in mediating membrane fusion.

Main Methods:

  • Analysis of physical principles governing membrane fusion.

Related Experiment Videos

  • Review of advanced models for bilayer fusion, moving beyond continuum approaches.
  • Examination of the functional role of SNARE proteins in the fusion process.

    • Main Results:

    • Recent advances provide a more detailed physical description of bilayer fusion.
    • New models offer insights into fusion mechanisms beyond traditional continuum approaches.
    • The involvement and mechanisms of SNARE proteins in fusion are increasingly elucidated.

    Conclusions:

    • While significant progress has been made, an integrated conceptual framework for protein-mediated membrane fusion is still lacking.
    • Further research is needed to fully reconcile lipid physics and protein-lipid interactions in fusion.
    • Open questions persist regarding the precise control and regulation of membrane fusion events.