Related Experiment Videos
Mutations in ribosomal protein L16 and in 23S rRNA in Enterococcus strains for which evernimicin MICs differ
Myriam Zarazaga1, Carmen Tenorio, Rosa Del Campo
1Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logroño, Spain.
Antimicrobial Agents and Chemotherapy
|October 18, 2002
Abstract:
Mutations in ribosomal protein L16 and in 23S rRNA were investigated in 22 Enterococcus strains of different species and for which the MICs of evernimicin differ (MICs, 0.023 to 16 micro g/ml). Amino acid changes (Arg56His, Ile52Thr, or Arg51His) in protein L16 were found in seven strains, and a nucleotide G2535A mutation in 23S rRNA was found in 1 strain among 13 for which the MICs are > or =1 micro g/ml.